All Publications


Goddard, L.M., Murphy, J.T., Org, T., Enciso, J.M., Hashimoto-Partyka, M.K., Warren, C.M., Domigan, C.K., McDonald, A.I., He, H., Sanchez, L.A., Allen, N.C., Orsenigo, F., Chao, L.C., Dejana, E., Tontonoz, P.,  Mikkola, H.K.A., Iruela-Arispe, M.L. 2014. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability pre-implantation. Cell.  In Press.


  Griffin, D.R., Borrajo, J., Soon, A., Acosta-Velez, G.F., Oshita, V., Darling, N., Mack, J., Barker, T., Iruela-Arispe, M.L., Segura, T. 2014.  Hybrid Photopatterned Enzymatic Reaction (HyPER) for in Situ Cell Manipulation.  Chembiochem.  Jan 7. Doi: 10.1002/cbic.201300687


Warren, C.M., Ziyad, S., Briot, A., Der, A., Iruela-Arispe, M.L.  2013.  A Ligand-Independent VEGFR2 Signaling Pathway Limits Angiogenic Responses in Diabetes.  Science Signaling.  7(307):ra1. Doi:10.1126/scisignal.2004235.


Corada, M., Orsenigo, F., Morini, M.F., Pitulescu, M. Bhat, G., Nyqvist, D., Breviario, F., Conti, V., Briot, A., Iruela-Arispe, M.L., Adams, R.H., Dejana, E.  2013. Sox17 is indispensable for acquisition and maintenance of arterial identity.  Nature Comm. 4:2609. doi: 10.1038/ncomms3609.  PMCID: PMC3826640.


Milde, F.,   Iruela-Arispe, M.L., Koumoutsakos, P. 2013.  The Mouse Retina in 3D: Quantification of vascular growth and remodeling.  Integrative Biol. 5(12): 1426-1438.


 Turlo, K.A., Scapa, J., Bagher, P., Jones, A.W., Feil, R., Korthuis, R.J., Segal, S.S., Iruela-Arispe, M.L. 2013.  b1-Integrin is essential for vasoregulation and smooth muscle survival In Vivo.  Arterioscler Thromb Vasc Biol.  33(10):2325-35.  PMCID: PMC3882010


Goddard, L.M., Ton, A.M., Org, T., Mikkola, H.K., Iruela-Arispe, M.L. 2013. Selective suppression of endothelial cytokine production by progesterone receptor. Vascul. Pharmacol. 59(1-2):36-43.  PMCID: PMC3819224.


 Janzen, D.M., Rosales, M.A., Paik, D.Y., Lee, D.S., Smith, D.A., Witte, O.N., Iruela-Arispe, M.L., Memarzadeh, S. 2013. Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy.Cancer Res. 73(15):4697-710. PMCID: PMC 3752407


 Roodhart, J.M.L., He, H., Daenen, L.G.M., Monvoisin, A., Barber, C., van Amersfoort, M., Hofmann, J.J., Radtke, F., Lane, T.F., Voest, E.E., and Iruela-Arispe, M.L. 2013.  Notch1 regulates angio-supportive bone-marrow-derived cells in mice: relevance to chemoresistance. Blood. 122(1):143-153. PMCID: PMC3701902.


Cristofaro, B., Shi, Y., Faria, M., Suchting, S., Leroyer, A.S., Trindade, A., Duarte, A., Zovein, A.C., Iruela-Arispe, M.L., Nih, L.R., Kubis, N., Henrion, D., Loufrani, L., Todiras, M., Schleifenbaum, J., Gollasch, M., Zhuang, Z.W., Simons, M., Eichmann, A., le Noble, F. 2013. Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models.  Development.  140:1720-1729.  (PMCID – N/A).


Defalco, T., Saraswathula,A., Briot, A., Iruela-Arispe, M.L., Capel, B. 2013. Testosterone levels influence mouse fetal leydig cell progenitors through Notch signaling. Biol. Reprod. 88(4):91, 1-12.  (PMCID – N/A).


Mack, J.J., Youssef, K., Noel, O.D., Lake, M.P., Wu, A., Iruela-Arispe, M.L., Bouchard, L.S. 2013.  Real-time maps of fluid flow field in porous biomaterials. Biomaterials. 34(8):1980-6. PMCID: PMC3714210


Howell M.D., Torres-Collado, A.X., Iruela-Arispe, M.L., Gottschall, P.E.  2012.  Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1.  PLoS One 7:e47226.  PMCID:  PMC3469530


 Hofmann J.J. Briot, A., Enciso, J., Zovein, A.C., Ren, S., Zhang, Z.W., Radtke, F., Simons, M., Wang, Y., Iruela-Arispe, M.L.  2012.  Endothelial deletion of murine Jagged1 leads to valve calcification and congenital heart defects associated with Alagille syndrome.  Development.  139:4449-4460.  PMCID: PMC3509736.


He, H., Xu, J., Warren, C.M., Duan, D., Wu, L., and Iruela-Arispe, M.L. 2012.  Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. Blood. 120:3152-3162.  PMCID: PMC3471522


Avraham-Davidi I, Ely Y, Pham VN, Castranova D, Grunspan M, Malkinson G, Gibbs-Bar L, Mayseless O, Allmog G, Lo B, Warren CM, Chen TT, Ungos J, Kidd K, Shaw K, Rogachev I, Wan W, Murphy PM, Farber SA, Carmel L, Shelness GS, Iruela-Arispe ML, Weinstein BM, Yaniv K. 2012.  ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor-1. Nature Med. 18(6):967-973.


Chhabra, A., Lechner, A.J., Ueno, M., Acharya, A., van Handel, B., Wang, Y., Iruela-Arispe, M.L., Tallquist, M.D., Mikkola, H.K. 2012.  Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.  Dev. Cell.  13:651-659.  (PMCID: PMC3395466).


 Hall-Glenn, F., De Young, R.A., Huang, B.L., van Handel, B., Hofmann, J.J., Chen, T.T., Choi, A., Ong, J.R., Benya, P.D., Mikkola, H., Iruela-Arispe, M.L., Lyons, K.M.  2012.  CCN2/Connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis.  PLoS One.  7(2):e30562. (PMCID: PMC3282727).


Turlo, K.A., Noel, O.D., Vora, R, LaRussa, M., Hall-Glenn, F., Iruela-Arispe, M.L. 2012.  An essential requirement for b1 integrin in the assembly of extracellular matrix proteins within the vascular wall.  Dev. Biol. 365(1):23-35. Evaluated as Exceptional (10) by Faculty of 1000. PMID: 22331032.  PMCID: PMC3590017.


 Cooley, M.A., Fresco, V.M., Dorlon, M.E., Twal, W.O., Lee, N.V., Barth, J.L., Kern, C.B., Iruela-Arispe, M.L., Argraves, W.S. 2012.  Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.  Dev. Dyn.  241(2):303-14.  PMCID: PMC3489172


 Scheppke, L., Murphy, E., Zarpellon, A., Hofmann, J.J., Merkulova, A., Shields, D., Weis, S., Byzova, T., Ruggeri, Z.,Iruela-Arispe, M.L., Cheresh, D.  2012. Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane.  Blood.  119(9):2149-58. PMCID:  PMC3311249


 Youssef K, Mack JJ, Iruela-Arispe ML, Bouchard LS. 2012. Macro-scale Topology Optimization for Controlling Internal Shear Stress in a Porous Scaffold Bioreactor. Biotechnol Bioeng. 109(7):1844-54. (PMCID – NA).


Anderson SM, Shergill B, Barry ZT, Manousiouthakis E, Chen TT, Botvinick E, Platt MO, Iruela-Arispe ML, and Segura T, “VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF.”  Integrative Biology 2011 (in press)


Michalak DJ, Xu S, Lowery TJ, Crawford CW, Ledbetter M, Bouchard LS, Wemmer DW, Budker D, Pines A, “Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry.” Magn. Reson. Med. 2011 (in press)


Iruela-Arispe ML, “LUMENating blood vessels.” Dev. Cell, 2011; 20: 412-414.


Sharma R, Taylor RE, Bouchard LS, “Intramolecular ligand dynamics in d15-(PPh3)-Capped Gold Nanoparticles Investigated by 2H NMR.” Journal of Physical Chemistry C 2011; 115: 3297-3303.


Corada M, Nyqvist D, Orsenigo F, Caprini A, Giampietro C, Taketo MM, Iruela-Arispe ML, Adams RH, Dejana E, “The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating DII4/Notch signaling.” Dev. Cell 2010; 18: 938-949.


McFadden C, Bouchard LS, “Universality of cluster dynamics.”  Phys. Rev. E 2010; 82; 061125(1-8).


Hofmann JJ, Zovein AC, Koh H, Radtke F, Weinmaster G, and Iruela-Arispe ML, “Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome.” Development 2010; 137: 4061-4072.


Zovein, AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML, “Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism.” Dev. Cell 2010; 18: 39-51.


Arroyo AG and Iruela-Arispe ML, “Extracellular matrix, inflammation, and the angiogenic response.” Cardiovasc. Res. 2010; 86:226-235. PMCID: PMC2856193


Warren CM and Iruela-Arispe ML, “Signaling circuitry in vascular morphogenesis.”  Curr Opin Hematol. 2010; 17 (3):213-218. PMCID: PMC2921923


Robson SA, Peterson R, Bouchard LS, Villareal VA, Clubb RT, “Heteronuclear Zero Quantum Coherence Nz-Exchange Experiment That Resolves Resonance Overlap and Its Application To Measure the Rates of Heme Binding to the IsdC Protein.” J. Am. Chem. Soc. 2010; 132(28): 9522-9523.


Priceman SJ, Sung, JL, Shaposhnik Z, Burton J B, Torres-Collado  AX, Moughon DL, Johnson M, Lusis AJ, Cohen DA, Iruela-Arispe ML and Wu L, “Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of anti-angiogenic of anti-angiogenic therapy.”  Blood 2010; 114(2):469-77. PMCID:  PMC2826767


Additional Publications


Arroyo, A.G. and Iruela-Arispe, M.L. 2010. Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res. 86:226-235. PMCID: PMC2856193


Warren, C.M. and Iruela-Arispe, M.L.  2010. Signaling circuitry in vascular morphogenesis. Curr Opin Hematol. 17 (3):213-218. PMCID: PMC2921923


Priceman, S.J., Sung, J.L., Shaposhnik, Z., Burton, J.B., Torres-Collado, A.X., Moughon, D.L., Johnson, M., Lusis, A.J., Cohen, D.A., Iruela-Arispe, M.L. and Wu, L.  2010.  Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of anti-angiogenic of anti-angiogenic therapy.  Blood 114(2):469-77. PMCID:  PMC2826767


Lee, Y.J., Koch, M., Karl, D., Torres-Collado, A.X., Fernando, N.T., Rothrock, C., Kuruppu, D., Ryeom S., Iruela-Arispe, M.L., Yoon, S.S. 2010. Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1. Cancer Res. 70(3):948-56. PMCID:  PMC2934910


Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemann A, Takeda N, Doedens A, Torres-Collado AX, Iruela-Arispe L, Nizet V, Johnson RS. 2010. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci U S A. 107(9):4329-34. PMCID: PMC2840078


Chen TT, Luque A, Lee S, Anderson SM, Segura T, Iruela-Arispe ML. 2010. Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol. 188(4):595-609. PMCID: PMC2828913


Da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kotourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, Iruela-Arispe ML, Dipersion CM, Kreidberg JA, Hodivala-Dilke KM.  2010. Endothelial alpha 3 beta1 integrin represses pathological angiogenesis and sustains endothelial VEGF.  Am. J. Pathol. 177(3):1534-48. PMCID: PMC2928983.


 Zovein AC, Turlo KA, Ponec RM, Lynch MR, Chen KC, Hofmann JJ, Cox TC, Gasson JC, Iruela-Arispe ML.  2010.  Vascular remodeling of the vitelline artery initiates extra-vascular emergence of hematopoietic clusters. Blood,  (Cover)  116(18):3435-44. PMID 20699440


Turlo KA, Gallaher SD, Vora R, Laski FA, Iruela-Arispe, ML.  2010.  When Cre-mediated recombination in mice does not result in protein loss.  Genetics,  – Highlighted by the Journal. 186(3):959-67. PMCID: PMC2975293